RNAi-mediated knockdown of FANCF suppresses cell proliferation, migration, invasion, and drug resistance potential of breast cancer cells

Fanconi anemia complementation group F protein (FANCF) is a key factor, which maintains the function of FA/BRCA, a DNA damage response pathway.However, the functional role of FANCF in breast cancer has not been elucidated.We performed a specific FANCF-shRNA knockdown of endogenous FANCF in vitro.Cell viability was measured with a CCK-8 assay.DNA da

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LncRNAs, nuclear architecture and the immune response

Long noncoding RNAs (LncRNAs) are key regulators of gene expression and click here can mediate their effects in both the nucleus and cytoplasm.Some of the best-characterized lncRNAs are localized within the nucleus, where they modulate the nuclear architecture and influence gene expression.In this read more review, we discuss the role of lncRNAs in

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